SELECT RECENT PUBLICATIONS

 
 

2025

Schuler, H., Iyer, E. S., Siemonsmeier, G., Weinbaum, A. M., Vitaro, P., Shen, S., & Bagot, R. C. (2025). Sex-specific exploration accounts for differences in valence learning in male and female mice. bioRxiv.

Herrera-Portillo, L., Gallino, D., Yee, Y., Munir, J., Devenyi, G. A., Bagot, R. C., & Chakravarty, M. M. (2025). Whole brain dimensional approach identifies shared and sex-specific networks of stress susceptibility in male and female mice. bioRxiv.

Iyer, E. S., Vitaro, P., Wu, S., Munir, J., Tse, Y. C., Cvetkovska, V., & Bagot, R. C. (2025). Reward integration in prefrontal-cortical and ventral-hippocampal nucelus accumbens inputs cooperatively modulates engagement. Nature Communications. 16(1):3573.

Zhou, D., Schuler, H., Cvetkovska, V., Meccia, J., Harutyunyan, A. S., Ragoussis, J., & Bagot, R. C. (2025). Single-cell sequencing reveals psilocybin induces sustained cell-type specific plasticity in mouse medial prefrontal cortex. bioRxiv.

 
 

2024

Munir, J., Iyer, E. S., Tse, Y. C., Sorensen, J., Wu, S., Eid, R. S., Cvetkovska, V., Wassef, K., Gostlin, S., Vitaro, P., Spencer, N. J., & Bagot, R. C. (2024). Sex-biased neural encoding of threat discrimination in nucelus accumbens afferents drives suppression of reward behaviour. Nature Neuroscience. 27(10):1966-1976.

Schuler, H., Eid, R. S., Wu, S., Tse, Y. C., Cvetkovska, V., Lopez, J., Quinn, R., Zhou, D., Meccia, J., Dion-Albert, L., Bennett, S. N., Newman, E. L., Trainor, B. C., Peña, C. J., Menard, C., & Bagot, R. C. (2024). Data-driven analysis identifies novel modulation of social behaviour in female mice witnessing chronic social defeat stress. Biological Psychiatry. 98(5):416-426.

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2023

 
 

2022

Iyer, E.S., Weinberg, A., & Bagot, R.C. (2022). Ambiguity and conflict: Dissecting uncertainty in decision-making. Behavioral Neuroscience. 136(1), 1-12.

 
 

2021

Lopez J. & Bagot R.C. (2021). Defining Valid Chronic Stress Models for Depression With Female Rodents. Biological Psychiatry. 90(4):226-235.

Guma E., Bordignon P.D.C., Devenyi G.A., Gallino D., Anastassiadis C., Cvetkovska V., Barry A.D., Snook E., Germann J., Greenwood C.M.T., Misic B., Bagot R.C., & Chakravarty M.M. (2021). Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study. Biological Psychiatry. 90(5):328-341.

 
 

2020

Muir, J., Tse, Y.C., Iyer, E.S., Biris, J., Cvetkovska, V., Lopez, J., & Bagot, R.,C.  Ventral-hippocampal afferents to nucleus accumbens encode both latent vulnerability and stress-induced susceptibility. Biological Psychiatry. 88(11):843-854.

Iyer, E.S., Kairiss, M.A., Liu, A., Otto, A. R., & Bagot, R.C. (2020). Probing relationships between reinforcement learning and simple behavioral strategies to understand probabilistic reward learning. Journal of Neuroscience Methods. 341:108777.

Heller, A.S., & Bagot, R.C. (2020). Is hippocampal replay a mechanism for anxiety and depression? JAMA Psychiatry. 77(4):431-432.

 
 

2019

Lorsch, Z.S, Hamilton, P.J., Ramakrishnan, A., Parise, E.M., Salery, M., Wright, W.J., Lepack, A.E., Mews, P., Issler, O., McKenzie, A., Zhou, X., Parise, L.F., Pirpinias, S.T., Ortiz Torres, I., Kronman, H.G., Montgomery, S.E., Loh, Y.E., Labonté, B., Conkey, A., Symonds, A.E., Neve, R.L., Turecki, G., Maze, I., Dong, Y., Zhang, B., Shen, L., Bagot, R.C., & Nestler, E.J. (2019). Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex. Nature Neuroscience. 22(9): 1413-1423.

Peña, C.J.,Nestler, E.J., & Bagot, R.C. Environmental programming of susceptibility and resilience in adulthood in male mice. Frontiers in Behavioral Neuroscience. 13:40.

Peña, C.J., Smith, M., Ramakrishnan, A., Cates, H.M., Bagot, R.C., Kronman, H.G., Patel, B., Chang, A.B., Purushothaman, I., Dudley, J., Morishita, H., Shen, L., & Nestler, E.J. (2019). Early life stress alters transcriptomic patterning across reward circuitry in male and female mice. Nature Communications. 10(1): 5098.

Sandre, A., Bagot, R.C. & Weinberg, A. (2019). Blunted neural response to appetitive images prospectively predicts symptoms of depression, and not anxiety, during the transition to university. Biological Psychology. 145: 31-41.

Muir, J., Lopez, J., & Bagot, R.C. (2019). Wiring the depressed brain: Optogenetic and chemogenetic circuit interrogation in animal models of depression. Neuropsychopharmacology. 44(6): 1013-1026.

 
 

2018

Muir, J., Bagot, R.C. (2018) Optogenetics: illuminating the neural circuits of depression. Quevedo, J., Carvalho, A.F., Zarate, C.A. (Ed). Neurobiology of Depression: A Road to Novel Therapeutics.

Lorsch, Z.S., Loh, Y.E., Purushothaman, I., Walker, D.M., Parise, E.M., Salery, M., Cahill, M.E., Hodes, G.E., Pfau, M.L., Kronman, H., Hamilton, P.J., Issler, O., Labonte, B., Symonds, A.E., Zucker, M., Zhang, T.Y., Meaney, M.J., Russo, S.J., Shen, L., Bagot, R.C., & Nestler, E.J. (2018). Estrogen receptor a drives pro-resilient transcription in mouse models of depression. Nature Communications. 9(1): 1116.

Muir, J., Lorsch, Z.S., Ramakrishnan, C., Deisseroth, K., Nestler, E.J., Calipari, E.S., & Bagot, R.C. (2018). In vivo fiber photometry reveals signature of future stress susceptibility in nucleus accumbens. Neuropsychopharmacology. 43(2): 255-263.

Hultman, R., Ulrich, K., Sachs, B.D., Blount, C., Carlson, D.E., Ndubuizu, N., Bagot, R.C., Parise, E.M., Vu, M.T., Gallagher, N.M., Wang, A.J., Deisseroth, K., Mague, S.D., Caron, M.G., Nestler, E.J., Carin, & L., Dzirasa, K. (2018). Brain-wide electrical spatiotemporal dynamics encode depression vulnerability. Cell. 8674(18) 30156-9.

 
 

2017

Peña, C.J., Kronman, H.G., Walker, D.M., Cates, H.M., Bagot, R.C., Purushothaman, I. Issler, O., Loh, Y.E., Leong, T., Kiraly, DD., Goodman, E., Neve, R.L., Shen, L., & Nestler, E.J. (2017). Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2. Science. 356(6343): 1185-1188.

Bagot, R.C., Cates, H.M., Purushothaman, I., Vialou, V., Heller, E.A., Yieh, L., LaBonté, B., Peña, C.J., Shen, L., Wittenberg, G.M. & Nestler, E.J. (2017). Ketamine and imipramine reverse transcriptional signatures of susceptibility and induce resilience-specific gene expression profiles. Biological Psychiatry. 81 (4): 285-295.

 
 

2016

Bagot, R.C., Cates, H.M., Purushothaman, I., Lorsch, Z.L., Walker, D.M., Wang, J., Huang. X., Schlüter, O., Maze, S., Peña, C.J., Heller, E.A., Issler, O., Wang, M, Song, W., Stein, J.L., Liu, X.C., Doyle, M.A., Scobie, K.N., Sun, H.S., Neve, R.L., Geschwind, D., Dong, Y., Shen, L., Zhang, B., & Nestler, E.J. (2016) Circuit-wide transcriptional profiling reveals region-specific gene networks regulating depression susceptibility. Neuron. 90(5): 969-83.

Calipari, E.S., Bagot, R.C., Purushothaman, I., Davidson, T.J., Yorgason, J.T., Peña, C.J., Walker, D.M., Pirpinias, S.T., Guise, K., Ramakrishnan, C., Deisseroth, K., & Nestler, E.J. (2016). In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward. Proceedings of the National Academy of Sciences.113(10): 2726-31.

 
 

2015

Bagot, R.C., Parise, E.M., Peña, C.J., Zhang, H.X., Maze, I., Chaudhury, D.C. Persaud, B., Cachope, R., Bolaños, C.A., Cheer, J., Deisseroth, K., Han, M.H., & Nestler, E.J. (2015). Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression-like behavior. Nature Communications. 6: 7062.

Nguyen, H.B., Bagot, R.C., Diorio, J., Wong, T.P., & Meaney, M.J. (2015). Maternal care differentially affects neuronal excitability and synaptic plasticity in the dorsal and ventral hippocampus. Neuropsychopharmacology. 40(7): 1509-9.